Canine leishmaniosis – new concepts and insights on an expanding zoonosis: part one


Baneth G, Koutinas A, Solano-Gallego L, Bourdeau P, Ferrer L
(Trends Parasitol. 2008, 24(7):324-30)


Recent research has generated new insights on epidemiology, pathology and immunology of canine leishmaniosis (CanL) and its genetic background. We now know that the prevalence of infection in endemic areas is considerably higher than that of apparent clinical illness. In addition, infection quickly spreads among dogs when optimal conditions for transmission occur. Infection induces granulomatous and harmful immune-mediated responses, and susceptibility to the disease is influenced by a complex genetic basis. These concepts will be instrumental for devising control programs. This review, the first in a series of two articles on CanL, presents an updated view on progress in elucidating the epidemiology and pathogenesis of this intriguing disease, and the second part focuses on progress in diagnosis, treatment and prevention.

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