Canine Leishmaniosis

Etiology, Distribution & Transmission
Canine Leishmania infections are due to a widely distributed species, Leishmania Infantum. However, in the new world and in the old world, other zoonotic species of…
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Clinical signs

Clinical Manifestations
Clinical manifestations and laboratory abnormalities found in CanL due to L. infantum. General: Generalized lymphadenomegaly, loss of body weight, decreased or increased appetite…
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Diagnostic approach

Diagnosis
 

Diagnosis is based on clinical signs and/or clinicopathological abnormalities compatible with disease and by confirmation of Leishmania infantum infection, using mainly serological…
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Clinical staging

Treatment and Prognosis
A system that classifies the disease into four stages with the goal of assisting the clinician in determining the appropriate therapy, forecasting prognosis…
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Treatment protocols

Therapy
 

Current treatment protocols for CanL.
Meglumine antimoniate, Miltefosine, Allopurinol and Domperidone.
Dose and main side effects…
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Monitoring
 

Recommended monitoring during and after treatment of CanL.
Parameters and frequency. Clinical history and physical examination…
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Prevention
Prevention should include the application of a long-acting topical insecticide throughout the period of sand fly activity. Additionally, vaccination might be considered.
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Vaccines
A vaccine based on purified excreted/secreted antigens of L. infantum has been licensed in Europe since 2011. This vaccine contains a saponin adjuvant…
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