Clinical Manifestations
Table 2. Main clinical signs and clinicopathological abnormalities found in CanL due to L. infantum
MAIN CLINICAL SIGNSGeneralLocalized or generalized lymphadenomegalyLoss of body weight Decreased appetite Lethargy Pale mucous membranes Splenomegaly Polyuria and polydipsia Fever Vomiting Diarrhea CutaneousExfoliative dermatitis with or without alopeciaErosive-ulcerative dermatitis Nodular dermatitis Papular dermatitis Pustular dermatitis Nails abnormalities OcularBlepharitis (exfoliative, ulcerative or nodular) and conjunctivitis (nodular)Keratoconjunctivitis, either common or sicca Anterior uveitis Endophtalmitis OtherMucocutaneous and mucosal ulcerative or nodular lesions (oral, genital and nasal)Epistaxis Lameness (erosive or non-erosive polyarthritis, osteomyelitis and polymyositis) Atrophic masticatory myositis Vascular disorders (systemic vasculitis and arterial thromboembolism) Neurological disorders |
CLINICOPATHOLOGICAL ABNORMALITIESCBC/HemostasisMild to moderate normocytic normochromic non-regenerative anemiaLeukocytosis or leukopenia: lymphopenia, neutrophilia, neutropenia Thrombocytopathy Thrombocytopenia Impaired secondary hemostasis and fibrinolysis Serum biochemical profile with proteins electrophoresisHyperproteinemiaHyperglobulinemia (polyclonal beta and/or gammaglobulinemia) Hypoalbuminemia Decreased albumin/globulin ratio Renal azotemia Elevated liver enzyme activities Proteinuria CBC: Complete blood count |
